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LymPhos is a database containing peptidic sequences and spectrometric information on the phosphoproteome of human T-Lymphocytes.
THE PHOSPHOPROTEOME
Protein phosphorylation-dephosphorylation events play a primordial role in almost all aspects of cell function including signal transduction, cell cycle and apoptosis. Phosphorylation is probably the most frequent reversible posttranslational modification of proteins (about 30% of the cell proteins are phosphorylated in a given condition). However, the number of known in vivo substrates of kinases is still low.

WHERE LYMPHOS COMES FROM?
Lymphos data has been obtained at the CSIC/UAB Proteomics Laboratory of the Superior Council of Scientifical Research mainly under a Spanish Research Project funded by Research and Education Ministry (BIO2004-01788) during the period 2004-2008. In this project we intend to study, using a proteomic approach, the phosphoproteome of resting and physiologically or pharmacologically activated T and B lymphocytes.
The main objective was the design of a coherent and comprehensive database of phosphoproteins and phosphorylation sites in these cells. The characterization of phosphorylation motifs will help in the search for new, physiologically relevant kinases as well as in the understanding of the mechanisms involved in the regulation of protein function. This information is the first step towards the design of new therapies based in drugs controlling either kinase/phosphatase activities or the activity of other proteins in key points of the affected pathways.

LYMPHOS DESIGN
Lymphos is a web-oriented database where phosphorylation sites can be searched for human lymphocytic proteins. It is possible to search for both proteins and for peptide sequences, or browse the entire database, where experimental data (commented mass spectra) will support every phosphorylation site assignment.
An accurate description of the experimental design can be found in Experimental.

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